Researchers have created the first mouse model demonstrating the role of a cancer promoting gene, Astrocyte elevated gene-1 (AEG-1, in liver cancer.
The mouse model represents a critical step in understanding the molecular mechanisms of liver cancer
progression and could lead to novel therapies for the disease. The mouse model represents a critical step in understanding the molecular mechanisms of liver cancer
AEG-1 was originally cloned in the lab of the study's co-author, Paul B. Fisher, M.Ph., Ph.D., Thelma Newmeyer Corman Endowed Chair in Oncology Research and program co-leader of Cancer Molecular Genetics at Massey, professor and chair of the Department of Human and Molecular Genetics and director of VIMM.
"My colleagues and I have been researching the role of AEG-1 in cancer development for several years and have shown it is linked to a diverse array of cancers, including liver cancer," Devanand Sarkar, from the Virginia Commonwealth University (VCU) School of Medicine, said.
"This mouse model represents a breakthrough in our ability to test and translate our laboratory findings," he said.
The mouse model gave the researchers a deeper understanding of the role of AEG-1 in liver cancer.
Sarkar and his team confirmed AEG-1 overexpression significantly accelerated the progression of liver cancer. It also caused steatosis, or fatty liver, a mechanism that promotes inflammation and cancer progression.
In addition, the mouse model substantiated laboratory findings that suggested that AEG-1 plays a role in protecting liver cancer cells from chemotherapeutic drugs and alters tumor angiogenesis, or the way that new blood vessels are formed within the tumor.
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